Prasad, BV Venkatram and Balaram, P (1982) X-Pro peptides. A theoretical study of the hydrogen bonded conformations of (a-aminoisobutyryl-L -prolyl)n sequences. In: International Journal of Biological Macromolecules, 4 (2). pp. 99-102.
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Intramolecularly hydrogen bonded conformations of (Aib-Pro)n sequences have been analysed theoretically. Both 4â��1 (C10 and 3â��1 (C7 hydrogen bonded regular structures are shown to be stereochemically feasible. Conformational energies for the helical structures have been estimated using classical potential energy methods. Both C10 and C7 conformations have very similar energies. Pyrrolidine ring puckering has a pronounced effect on the energies, and only CÎ³-endo puckered Pro residues can be accommodated. The theoretical calculations using spectroscopic data suggest that the recently proposed novel 310 helical conformation for benzyloxycarbonyl(Aib-Pro)4-methyl ester is in solution, is indeed energetically and stereochemically favourable.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Publisher.|
|Keywords:||Polypeptide; stereochemistry; proline; α-aminoisobutyryl peptides|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||15 Dec 2009 06:43|
|Last Modified:||19 Sep 2010 05:46|
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