Maneckjee, Rhoda and Raj, HG Madhawa and Moudgal, NR (1973) Comparative mparative Effects of Antiserum to Luteinizing Hormone on Pseudopregnancy and Pregnancy Induced in the Same Rat. In: Biology of Reproduction, 8 (1). pp. 43-47.
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The comparative role of luteinizing hormone (LH) in maintaining pregnancy and histamine-induced decidualization in the rat was studied with the help of a new system, wherein the above two states could be brought about simultaneously in the same animal, but in different uterine horns. Specific and well-characterized LH antiserum, administered daily, both during the pre-trauma (days 1-4) and post-trauma (days 5-8) periods, resulted in the termination of pregnancy and inhibition of decidualization. This antiserum effect could be reversed by suitable steroid therapy. Results suggest that the antiserum blockade of ovarian steroidogenesis continued even after cessation of its treatment. Early pregnancy and decidualization seem directly comparable in that both are dependent upon LH to stimulate the ovarian synthesis of much-needed progesterone and estrogen.
|Item Type:||Journal Article|
|Additional Information:||Copy right of this article belongs to Society for the Study of Reproduction.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||18 Jan 2010 10:16|
|Last Modified:||19 Sep 2010 05:46|
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