Doerig, C and Baker, D and Billker, O and Blackman, MJ and Chitnis, C and Kumar, Dhar S and Heussler, V and Holder, AA and Kocken, C and Krishna, S and Langsley, G and Lasonder, E and Menard, R and Meissner, M and Pradel, G and Ranford-Cartwright, L and Sharma, A and Sharma, P and Tardieux, T and Tatu, Utpal and Alano, P (2009) Signalling in Malaria Parasites the Malsig Consortium. In: Parasite-Journal De La Societe Francaise De Parasitologie, 16 (3). pp. 169-182. (In Press)Full text not available from this repository.
Depending on their developmental stage in the life cycle, malaria parasites develop within or outside host cells, and in extremely diverse contexts such as the vertebrate liver and blood circulation, or the insect midgut and hemocoel. Cellular and molecular mechanisms enabling the parasite to sense and respond to the intra- and the extra-cellular environments are therefore key elements for the proliferation and transmission of Plasmodium, and therefore are, from a public health perspective, strategic targets in the fight against this deadly disease. The MALSIG consortium, which was initiated in February 2009, was designed with the primary objective to integrate research ongoing in Europe and India on i) the properties of Plasmodium signalling molecules, and ii) developmental processes occurring at various points of the parasite life cycle. On one hand, functional studies of individual genes and their products in Plasmodium falciparum (and in the technically more manageable rodent model Plasmodium berghei) are providing information on parasite protein kinases and phosphatases, and of the molecules governing cyclic nucleotide metabolism and calcium signalling. On the other hand, cellular and molecular studies are elucidating key steps of parasite development such as merozoite invasion and egress in blood and liver parasite stages, control of DNA replication in asexual and sexual development, membrane dynamics and trafficking, production of gametocytes in the vertebrate host and further parasite development in the mosquito. This article, which synthetically reviews such signalling molecules and cellular processes, aims to provide a glimpse of the global frame in which the activities of the MALSIG consortium will develop over the next three years.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to PRINCEPS Editions|
|Keywords:||malaria; Plasmodium; Toxoplasma; signalling|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||08 Jan 2010 05:15|
|Last Modified:||08 Jan 2010 05:15|
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