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Thiol-Disulfide Interchange Mediated Reversible Dendritic Megamer Formation and Dissociation

Kiran, Balaji Manjappa and Jayaraman, Narayanaswamy (2009) Thiol-Disulfide Interchange Mediated Reversible Dendritic Megamer Formation and Dissociation. In: Macromolecules, 42 (19). pp. 7353-7359.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ma9010022

Abstract

We report the formation of dynamic, reversible cross-linked dendritic megamers and their dissociation to monomeric dendrimers, through a thiol-disulfide interchange reaction. For this study, poly(alkyl aryl ether) dendrimers up to three-generations presenting thiol functionalities, were prepared. The series from zero to three generations of dendrimers were installed with 3, 6, 12, and 24 thiol functionalities at their peripheries. Upon synthesis, cross-linking of the dendrimer was accomplished through disulfide bond formation. The cross-linking of dendrimers was monitored through optical density changes at 420 nm. Dense cross-linking led to visible precipitation of dendritic megamers and the morphologies of the megamers were characterized by transmission electron microscopy. The disulfide cross-links between megamer monomers could be dissociated readily upon reduction of disulfide bond by dithiothreitol reagent. Preliminary studies show that dendritic megamers encapsulate C-60 and the efficiency of encapsulation increased with increasing generation of dendritic megamer.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Chemical Society, 2009.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 20 Dec 2009 09:07
Last Modified: 19 Sep 2010 05:50
URI: http://eprints.iisc.ernet.in/id/eprint/24524

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