Omkumar, RV and Gaikwad, Amos S and Ramasarma, T (1992) Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone. In: Biochemical and Biophysical Research Communications, 184 (3). pp. 1280-1287.
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Abstract
Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone indicating a possible feedback type of action.
| Item Type: | Journal Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier Science. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 16 Dec 2009 04:44 |
| Last Modified: | 19 Sep 2010 05:51 |
| URI: | http://eprints.iisc.ernet.in/id/eprint/24625 |
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