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Gene therapy: Principles, practice, problems and prospects

Rangarajan, PN and Padmanaban, G (1996) Gene therapy: Principles, practice, problems and prospects. In: Current Science, 71 (5). 360 -368.

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Abstract

The remarkable advances made in recombinant DNA technology over the last two decades have paved way for the use of gene transfer to treat human diseases. Several protocols have been developed for the introduction and expression of genes in humans, but the clinical efficacy has not been conclusively demonstrated in any of them. The eventual success of gene therapy for genetic and acquired disorders depends on the development of better gene transfer vectors for sustained, long term expression of foreign genes as well as a better understanding of the pathophysiology of human diseases, it is heartening to note that some of the gene therapy protocols have found other applications such as the genetic immunization or DNA vaccines, which is being heralded as the third vaccine revolution, Gene therapy is yet to become a dream come true, but the light is seen at the end of the tunnel.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Human cftr cdna;hemagglutinin-neuraminidase;adenoassociated virus;bone-marrow;expression;invivo;delivery;adenovirus; vectors;cancer.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 27 Jan 2010 10:06
Last Modified: 27 Jan 2010 10:06
URI: http://eprints.iisc.ernet.in/id/eprint/24680

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