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Theoretical calculations of base-base interactions in nucleic acids: II Stacking interactions in polynucleotides

Gupta, Goutam and Sasisekharan, V (1978) Theoretical calculations of base-base interactions in nucleic acids: II Stacking interactions in polynucleotides. In: Nucleic Acids Research, 5 (5). pp. 1655-1673.

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Official URL: http://nar.oxfordjournals.org/cgi/content/abstract...

Abstract

Base-base interactions were computed for single- and double- stranded polynucleotides, for all possible base sequences. In each case, both right and left stacking arrangements are energetically possible. The preference of one over the other depends upon the base-sequence and the orientation of the bases with respect to helix-axis. Inverted stacking arrangement is also energetically possible for both single- and double-stranded polynucleotides. Finally, interaction energies of a regular duplex and the alternative structures3 were compared. It was found that the type II model3 is energetically more favourable than the rest.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Oxford University Press.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 17 Dec 2009 06:20
Last Modified: 17 Dec 2009 06:20
URI: http://eprints.iisc.ernet.in/id/eprint/24903

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