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Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems - A novel class of potential antibacterial, antifungal and antitubercular agents

Mallikarjuna, BP and Sastry, BS and Kumar, Suresh GV and Rajendraprasad, Y and Chandrashekar, SM and Sathisha, K (2009) Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems - A novel class of potential antibacterial, antifungal and antitubercular agents. In: European Journal of Medicinal Chemistry, 44 (11). pp. 4739-4746.

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Abstract

In the present study a series of 4-isopropylthiazole-2-carbohydrazide analogs, derived clubbed oxadiazole-thiazole and triazole-thiazole derivatives have been synthesized and characterized by IR, H-1 NMR, C-13 NMR, elemental and mass spectral analyses. The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal and antitubercular activity against Mycobacterium tuberculosis H(37)Rv strain by broth dilution assay method. The synthesized compounds 7a, 7b, 7d and 4 showed an antitubercular efficacy considerably greater than that of the parent 4-isopropyl-1,3-thiazole-2-carbohydrazide 1, suggesting that the substituted 4-isopropylthiazole-2-carbohydrazide moiety plays an important role in enhancing the antitubercular properties of this class of compounds. Compounds 2c, 3, 4, 6d, 7a and 7b exhibited good or moderate antibacterial and antifungal activity. Compounds 4 and 7b showed appreciable cytotoxicity at a concentration of 250 mu M.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier Science.
Keywords: 4-Isopropylthiazole-2-carbohydrazide analogs; Clubbed triazole-thiazole derivatives; Antibacterial; Antifungal; Cytotoxicity; Antitubercular; Broth dilution assay
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 02 Dec 2009 05:07
Last Modified: 19 Sep 2010 05:52
URI: http://eprints.iisc.ernet.in/id/eprint/24990

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