Alok, Anshula and Karande, Anjali A (2009) The role of glycodelin as an immune-modulating agent at the feto-maternal interface. In: International Congress on Bio-Immunoregulatory Mechanisms Associated with Reproductive Organs, FEB 09-13, 2009, New Delhi, INDIA, pp. 124-127.
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Glycodelin A is a progesterone-induced endometrial glycoprotein which has been amply documented to play a role in down-modulation of the maternal immune response to fetal allo-antigens and to be indispensable for the maintenance and progression of pregnancy. Earlier studies from our laboratory have focused on the effect of glycodelin on T cells, key regulators of both the antibody and cell-mediated arms of the acquired immune system. Glycodelin-induced apoptosis inactivated T cells occurs through a caspase-dependant intrinsic mitochondrial pathway. Interestingly, glycodelin inhibited the proliferation of B cells but did not induce apoptosis. More recently, we have studied the effect of glycodelin on the cells of the innate immune system, namely monocytes and NK cells. We have found that glycodelin induced apoptosis in monocytic cells before their differentiation to macrophages, via the mitochondrial pathway, but did not affect their phagocytic capacity after differentiation. Glycodelin induced apoptosis in NK cells but this activity was independent of caspases. In conclusion, glycodelin is observed to affect many cells of the immune system, although the nature of the effect and signaling mechanisms involved in each cell type may be distinct.
|Item Type:||Conference Paper|
|Additional Information:||Copyright for this article belongs to Elsevier Science.|
|Keywords:||Glycodelin; Fetal-tolerance; Immune cells; Apoptosis; Cell proliferation|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry
Division of Chemical Sciences > NMR Research Centre (Formerly SIF)
|Date Deposited:||12 Jan 2010 08:58|
|Last Modified:||19 Sep 2010 05:54|
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