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Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system

Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, P (1981) Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system. In: Journal of the American Chemical Society, 103 (11). pp. 3213-3215.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja00401a050?pr...

Abstract

In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization.

Item Type: Editorials/Short Communications
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Feb 2010 08:48
Last Modified: 19 Sep 2010 05:55
URI: http://eprints.iisc.ernet.in/id/eprint/25679

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