Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, P (1981) Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system. In: Journal of the American Chemical Society, 103 (11). pp. 3213-3215.
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In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization.
|Item Type:||Editorials/Short Communications|
|Additional Information:||Copyright of this article belongs to American Chemical Society.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||19 Feb 2010 08:48|
|Last Modified:||19 Sep 2010 05:55|
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