Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system

Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, P (1981) Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system. In: Journal of the American Chemical Society, 103 (11). pp. 3213-3215.

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Abstract

In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization.

Item Type:	Editorials/Short Communications
Additional Information:	Copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Feb 2010 08:48
Last Modified:	19 Sep 2010 05:55
URI:	http://eprints.iisc.ernet.in/id/eprint/25679

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