Sharma, Rakesh K and Nethaji, Munirathnam and Samuelson, Ashoka G (2008) Asymmetric allylic alkylation by palladium-bisphosphinites. In: Tetrahedron: Asymmetry, 19 (6). pp. 655-663.
http___www.sciencedirect.com_science__ob=MImg&_imagekey=B6THT-4S6G4TT-7-29&_cdi=5291&_user=512776&_pii=S0957416608001262&_orig=search.pdf - Published Version
Restricted to Registered users only
Download (1594Kb) | Request a copy
A series of new chiral palladium-bisphosphinite complexes have been prepared from readily available, naturally occurring chiral alcohols. The complexes were used to efficiently carry out catalytic allylic alkylation of 1,3-diphenylpropene-2-yl acetate with dimethyl malonate. The complexes based on derivatives of ascorbic acid carry out enantioselective alkylations, one of which showed an ee as high as 97%. Based on the structural characterization, it can be surmised that strategic placement of phenyl groups is key to higher enantioselectivities.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||08 Mar 2010 10:45|
|Last Modified:||19 Sep 2010 05:56|
Actions (login required)