Rao, GSR Subba and Kondaiah, Paturu and Singh, Sanjay K and Ravanan, Palaniyandi and Sporn, Michael B (2008) Chemical modifications of natural triterpenes—glycyrrhetinic and boswellic acids: evaluation of their biological activity. In: Tetrahedron Letters, 64 (51). pp. 11541-11548.
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Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid, and boswellic acids, by modification of A-ring with a cyano- and enone-functionality, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bioassays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyano-enones of boswellic acid and glycyrrhetinic acid.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Chemical Sciences > Organic Chemistry
|Date Deposited:||09 Mar 2010 09:22|
|Last Modified:||19 Sep 2010 05:56|
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