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Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential

Parida, R and Shaila, MS and Mukherjee, S and Chandra, NR and Nayak, Rabindranath (2007) Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential. In: Vaccine, 25 (43). pp. 7530-7539.

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Official URL: http://dx.doi.org/10.1016/j.vaccine.2007.08.044

Abstract

The existing vaccines against influenza are based on the generation of neutralizing antibody primarily directed against surface proteins-hernagglutinin and neuraminidase. In this work, we have computationally defined conserved T cell epitopes of proteins of influenza virus H5N1 to help in the design of a vaccine with haplotype specificity for a target population. The peptides from the proteome of H5NI irus which are predicted to bind to different HLAs, do not show similarity with peptides of human proteorne and are also identified to be generated by proteolytic cleavage. These peptides could be made use of in the design of either a DNA vaccine or a subunit vaccine against V influenza. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Information Sciences > BioInformatics Centre
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 10 Jun 2010 05:56
Last Modified: 19 Sep 2010 05:56
URI: http://eprints.iisc.ernet.in/id/eprint/26154

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