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Conformationally locked thiosugars alpha-mannosidase inhibitors: Synthesis, and docking studies as potent biochemical

Slvapriya, K and Hariharaputran, S and Suhas, VL and Chandra, N and Chandrasekaran, Srinivasan (2007) Conformationally locked thiosugars alpha-mannosidase inhibitors: Synthesis, and docking studies as potent biochemical. In: Bioorganic & Medicinal Chemistry, 15 (17). pp. 5659-5665.

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Official URL: http://dx.doi.org/10.1016/j.bmc.2007.06.011

Abstract

series of thiosugar derivatives (thiolevomannosans) derived from mannose were synthesized and their inhibitory activity was tested against alpha-mannosidase (jack bean). These inhibitors were found to be more potent than the well-known inhibitors like kifunensine and deoxymannojirimycin based on docking and biochemical studies. The sulfone derivative 10 was shown to be the best inhibitor of alpha-mannosidase with the K-i value of 350 nM. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Information Sciences > Supercomputer Education & Research Centre
Division of Chemical Sciences > Organic Chemistry
Date Deposited: 10 Jun 2010 10:33
Last Modified: 19 Sep 2010 05:57
URI: http://eprints.iisc.ernet.in/id/eprint/26220

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