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Ion pairs in non-redundant protein structures

Shankar, BA Gowri and Sarani, R and Michael, Daliah and Mridula, P and Ranjani, C Vasum and Sowmiya, G and Vasundhar, B and Sudha, P and Jeyakanthan, J and Velmurugan, D and Sekar, K (2007) Ion pairs in non-redundant protein structures. In: Journal of Biosciences, 32 (4). pp. 693-704.

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Abstract

Ion pairs contribute to several functions including the activity of catalytic triads, fusion of viral membranes, stability in thermophilic proteins and solvent-protein interactions. Furthermore, they have the ability to affect the stability of protein structures and are also a part of the forces that act to hold monomers together. This paper deals with the possible ion pair combinations and networks in 25% and 90% non-redundant protein chains. Different types of ion pairs present in various secondary structural elements are analysed. The ion pairs existing between different subunits of multisubunit protein structures are also computed and the results of various analyses are presented in detail. The protein structures used in the analysis are solved using X-ray crystallography, whose resolution is better than or equal to 1.5 angstrom and R-factor better than or equal to 20%. This study can, therefore, be useful for analyses of many protein functions. It also provides insights into the better understanding of the architecture of protein structure.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre: Division of Information Sciences > BioInformatics Centre
Division of Information Sciences > Supercomputer Education & Research Centre
Date Deposited: 30 Mar 2010 11:52
Last Modified: 02 Nov 2011 05:47
URI: http://eprints.iisc.ernet.in/id/eprint/26274

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