Inferring molecular function: contributions from functional linkages

Medrano-Soto, Arturo and Pal, Debnath and Eisenberg, David (2008) Inferring molecular function: contributions from functional linkages. In: Trends in Genetics, 24 (12). 587 -590.

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Abstract

In the current era of high-throughput sequencing and structure determination, functional annotation has become a bottleneck in biomedical science. Here, we show that automated inference of molecular function using functional linkages among genes increases the accuracy of functional assignments by >= 8% and enriches functional descriptions in >= 34% of top assignments. Furthermore, biochemical literature supports >80% of automated inferences for previously unannotated proteins. These results emphasize the benefit of incorporating functional linkages in protein annotation.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Information Sciences > Supercomputer Education & Research Centre Division of Information Sciences > BioInformatics Centre
Date Deposited:	23 Mar 2010 12:03
Last Modified:	19 Sep 2010 05:58
URI:	http://eprints.iisc.ernet.in/id/eprint/26486

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