Medrano-Soto, Arturo and Pal, Debnath and Eisenberg, David (2008) Inferring molecular function: contributions from functional linkages. In: Trends in Genetics, 24 (12). 587 -590.
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In the current era of high-throughput sequencing and structure determination, functional annotation has become a bottleneck in biomedical science. Here, we show that automated inference of molecular function using functional linkages among genes increases the accuracy of functional assignments by >= 8% and enriches functional descriptions in >= 34% of top assignments. Furthermore, biochemical literature supports >80% of automated inferences for previously unannotated proteins. These results emphasize the benefit of incorporating functional linkages in protein annotation.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Information Sciences > Supercomputer Education & Research Centre
Division of Information Sciences > BioInformatics Centre
|Date Deposited:||23 Mar 2010 12:03|
|Last Modified:||19 Sep 2010 05:58|
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