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Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments

Limaye, Anil M and Asangani, Irfan and Bora, Namrata and Kondaiah, Paturu (2007) Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments. In: Asian Journal of Andrology, 9 (6). pp. 801-808.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/17968466

Abstract

Aim: To identify flutamide regulated genes in the rat ventral prostate. Methods: Total RNA from ventral prostates control and flutamide treated rats were isolated. Differentially expressed transcripts were identified using display reverse transcriptase polymerase chain reaction. The effect of castration on the expression of regulated transcripts was studied. Results: We have identified beta 2-microglobulin, cytoplasmic FMR1 protein 2 and pumilio 1 as flutamide induced and spermine binding protein and ribophorin II as flutamide targets in the rat ventral prostate. Although flutamide treatment caused an induction of pumilio I mRNA, had no effect. Conclusion: Castration and flutamide treatments exert differential effects on gene expression. might also have direct AR independent effects, which might have implications in the emergence of androgen dent prostate cancer and the failure of flutamide therapy.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Chinese Electronic Periodical Services.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited: 10 Jun 2010 09:11
Last Modified: 10 Jun 2010 09:11
URI: http://eprints.iisc.ernet.in/id/eprint/26573

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