Arany, Praveen R (2008) Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF-β1. In: 2nd International Engineering Conference on Light-Activated Tissue Regeneration and Therapy, JUN 24-29, 2007, Tomar.
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Laser mediated stimulation of biological process was amongst its very first effects documented by Mester et al. but the ambiguous and tissue-cell context specific biological effects of laser radiation is now termed ‘Photobiomodulation’. We found many parallels between the reported biological effects of lasers and a multiface-ted growth factor, Transforming Growth Factor-β (TGF-β). This review outlines the interestingparallelsbetween the twofieldsand our rationalefor pursuingtheir potential causal correlation. We explored this correlation using an in vitro assay systems and a human clinical trial on healing wound extraction sockets that we reported in a recent publication. In conclusion we report that low power laser irradiation can activate latent TGF-β1 and β3 complexes and suggest that this might be one of the major modes of the photobiomodulatory effects of low power lasers.
|Item Type:||Conference Paper|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||Low power laser therapy;photobiomodulation;latent;TGF;beta1 activation;laser medicine;wound healing;oral wounds;redox sensing.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)|
|Date Deposited:||29 Mar 2010 11:43|
|Last Modified:||19 Sep 2010 05:58|
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