Mehta, Goverdhan and Umarye, Jayant D (2002) Studies toward the Total Synthesis of Diterpene Antibiotic Guanacastepene A: Construction of the Hydroazulenic Core. In: Organic Letters, 4 (7). pp. 1063-1066.
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As a part of studies aimed toward the total synthesis of biologically important natural product guanacastepene A of contemporary interest,a new and concise route to a fully functionally endowed hydroazulenic core is delineated. The strategy involves the building of the requisite stereochemical features on a endo-tricyclo[5.2.1.02,6]decane matrix and excision of the five-membered ring through a retro-Diels-Alder reaction.Generation of the seven-membered ring to access the hydroazulenic framework was achieved employing ring closure metathesis (RCM)reaction as the key step.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to American Chemical Society.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||24 Jan 2005|
|Last Modified:||19 Jan 2012 06:03|
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