Gangadhar, Vidya and Jeyakani, Justin J and Shaila, MS and Nayak, Rabindranath and Chandra, Nagasuma (2007) Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides. In: Biochemical and Biophysical Research Communications, 364 (2). pp. 308-312.
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Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation. (C)) 2007 Elsevier Inc. All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Information Sciences > BioInformatics Centre
Division of Biological Sciences > Microbiology & Cell Biology
|Date Deposited:||09 Jun 2010 08:45|
|Last Modified:||19 Sep 2010 05:59|
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