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Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides

Gangadhar, Vidya and Jeyakani, Justin J and Shaila, MS and Nayak, Rabindranath and Chandra, Nagasuma (2007) Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides. In: Biochemical and Biophysical Research Communications, 364 (2). pp. 308-312.

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Official URL: http://dx.doi.org/10.1016/j.bbrc.2007.10.005

Abstract

Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation. (C)) 2007 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Information Sciences > BioInformatics Centre
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 09 Jun 2010 08:45
Last Modified: 19 Sep 2010 05:59
URI: http://eprints.iisc.ernet.in/id/eprint/26805

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