Ternary Iron(III) complex showing photocleavage of DNA in the photodynamic therapy window

Roy, Mithun and Saha, Sounik and Patra, Ashis K and Nethaji, Munirathinam and Chakravarty, Akhil R (2007) Ternary Iron(III) complex showing photocleavage of DNA in the photodynamic therapy window. In: Inorganic Chemistry, 46 (11). pp. 4368-4370.

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Abstract

A new ternary iron(III) complex [FeL(dpq)] containing dipyridoquinoxaline (dpq) and 2,2-bis(3,5-di-tert-butyl-2-hydroxybenzyl)aminoacetic acid (H3L) is prepared and structurally characterized by X-ray crystallography. The high-spin complex with a FeN3O3 core shows a quasi-reversible iron(III)/iron(II) redox couple at -0.62 V (vs SCE) in DMF/0.1 M TBAP and a broad visible band at 470 nm in DMF/Tris buffer. Laser photoexcitation of this phenolate (L)-to-iron(III) charge-transfer band at visible wavelengths including red light of >= 630 nm leads to cleavage of supercoiled pUC19 DNA to its nicked circular form via a photoredox pathway forming hydroxyl radicals.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	09 Jun 2010 07:23
Last Modified:	19 Sep 2010 05:59
URI:	http://eprints.iisc.ernet.in/id/eprint/26876

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