Mehta, Goverdhan and Mohal, Narinder (2000) A norbornyl route to azasugars: a new synthesis of deoxynojirimycin analogues. In: Tetrahedron Letters, 41 (30). pp. 5741-5745.
A new synthesis of deoxynojirimycin (DNJ) analogues (galacto-and altrose configuration) has been achieved through a functionalized cyclopentene derivative crafted from the norbornyl system, employing double reductive amination as the key step. The new DNJ analogues have been evaluated against various glycosidases and found to be moderate to strong inhibitors.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Elsevier Science.|
|Keywords:||azasugars;glycosidase inhibitors;osmylation;reductive amination|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||03 Feb 2005|
|Last Modified:||19 Sep 2010 04:17|
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