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Synthesis, Characterization and Evaluation of Cytotoxicity of New Aminophosphonic Acid Diesters in Human Leukemia Cells

Balakrishna, Avula and Chiruvella, Kishore K and Reddy, Mudumala VN and Reddy, Rajesh and Nayak, Sandip K and Raghavan, Sathees C and Reddy, Cirandur S (2010) Synthesis, Characterization and Evaluation of Cytotoxicity of New Aminophosphonic Acid Diesters in Human Leukemia Cells. In: Letters in Drug Design and Discovery, 7 (4). pp. 250-259.

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Abstract

A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, H-1, C-13, P-31, F-19 NMR, and mass spectra. All the title compounds were evaluated forin vitro cytotoxicity against leukemic cell line derived from T-cells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g (with IC50 value of 6 mu M) had emerged as lead compound.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Bentham Science Publishers.
Keywords: Aminophosphonate;Fluorine;TMG;Synthesis;Leukmia;CEM cell;Cytotoxicity
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 09 Jun 2010 07:36
Last Modified: 09 Jun 2010 07:36
URI: http://eprints.iisc.ernet.in/id/eprint/26997

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