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A Unique Nickel System having Versatile Catalytic Activity of Biological Significance

Chattopadhyay, Tanmay and Mukherjee, Madhuparna and Mondal, Arindam and Maiti, Pali and Banerjee, Arpita and Banu, Kazi Sabnam and Bhattacharya, Santanu and Roy, Bappaditya and Chattopadhyay, DJ and Mondal, Tapan Kumar and Nethaji, Munirathinam and Zangrando, Ennio and Das, Debasis (2010) A Unique Nickel System having Versatile Catalytic Activity of Biological Significance. In: Inorganic Chemistry, 49 (7). pp. 3121-3129.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ic901546t

Abstract

A new dinuclear nickel(II) complex, [Ni-2(LH2)(H2O)(2)(OH)(NO3)](NO3)(3) (1), of an ``end-off'' compartmental ligand 2,6-bis(N-ethylpiperazine-iminomethyl)-4-methyl-phenolato, has been synthesized and structurally characterized. The X-ray single crystal structure analysis shows that the piperazine moieties assume the expected chair conformation and are protonated. The complex 1 exhibits versatile catalytic activities of biological significance, viz. catecholase, phosphatase, and DNA cleavage activities, etc. The catecholase activity of the complex observed is very dependent on the nature of the solvent. In acetonitrile medium, the complex is inactive to exhibit catecholase activity. On the other hand, in methanol, it catalyzes not only the oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) but also tetrachlorocatechol (TCC), a catechol which is very difficult to oxidize, under aerobic conditions. UV vis spectroscopic investigation shows that TCC oxidation proceeds through the formation of an intermediate. The intermediate has been characterized by an electron spray ionizaton-mass spectrometry study, which suggests a bidentate rather than a monodentate mode of TCC coordination in that intermediate, and this proposition have been verified by density functional theory calculation. The complex also exhibits phosphatase (with substrate p-nitrophenylphosphate) and DNA cleavage activities. The DNA cleavage activity exhibited by complex 1 most probably proceeds through a hydroxyl radical pathway. The bioactivity study suggests the possible applications of complex 1 as a site specific recognition of DNA and/or as an anticancer agent.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 09 Jun 2010 05:41
Last Modified: 04 Jan 2013 07:16
URI: http://eprints.iisc.ernet.in/id/eprint/27133

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