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Replication of Japanese encephalitis virus in mouse brain induces alterations in lymphocyte response

Kavitha, Y and Thomas, S and Damodaran, A and Ramakrishna, L and Ranga, U and Manjunath, R (2007) Replication of Japanese encephalitis virus in mouse brain induces alterations in lymphocyte response. In: Acta Virologica, 51 (3). pp. 179-187.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/18076308

Abstract

The experimental model using intracerebral (i.c.) challenge was employed in many studies evaluating the protection against disease induced by Japanese encephalitis virus (JEV). We investigated alterations in peripheral lymphocyte response caused by i.c. infection of mice with JEV. Splenocytes from the i.c.-infected mice showed suppressed proliferative response to concanavalin A (con A) and anti-CD3 antibody stimulation. At the same time, the expression of CD25 (IL-2R) and production of IL-2 was inhibited. Addition of anti-CD28 antibody restored the decreased anti-CD3 antibody-mediated proliferation in the splenocytes. Moreover, the number of con A-stimulated cells secreting IL-4 was significantly reduced in splenocytes from i.c.-infected mice. These studies suggested that the i.c. infection with JEV might involve additional immune modulation effects due to massive virus replication in the brain.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Academic Electronic Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 20 May 2010 06:15
Last Modified: 20 May 2010 06:15
URI: http://eprints.iisc.ernet.in/id/eprint/27154

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