Gowd, KH and Sabareesh, V and Sudarslal, S and Iengar, P and Franklin, B and Fernando, A and Dewand, K and Ramaswami, M and Sarma, SP and Sikdar, S and Balaram, P and Krishnan, KS (2005) Novel peptides of therapeutic promise from Indian Conidae. In: 1st International Conference on Natural Products and Molecular Medicine, JAN 13-15, 2005, Univ Cape Town.
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Highly structured small peptides are the major toxic constituents of the venom of cone snails, a family of widely distributed predatory marine molluscs. These animals use the venom for rapid prey immobilization. The peptide components in the venom target a wide variety of membrane-bound ion channels and receptors. Many have been found to be highly selective for a diverse range of mammalian ion channels and receptors associated with pain-signaling pathways. Their small size, structural stability, and target specificity make them attractive pharmacologic agents. A select number of laboratories mainly from the United States, Europe, Australia, Israel, and China have been engaged in intense drug discovery programs based on peptides from a few snail species. Coastal India has an estimated 20-30% of the known cone species; however, few serious studies have been reported so far. We have begun a comprehensive program for the identification and characterization of peptides from cone snails found in Indian Coastal waters. This presentation reviews our progress over the last 2 years. As expected from the evolutionary history of these venom components, our search has yielded novel peptides of therapeutic promise from the new species that we have studied.
|Item Type:||Conference Paper|
|Additional Information:||Copy right of this article belongs to John Wiley and Sons.|
|Keywords:||novel peptides; Conidae; molluscs; contryphans.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||29 Apr 2010 11:06|
|Last Modified:||19 Sep 2010 06:01|
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