Backbone chemical shift assignments of the acyl-acyl carrier protein intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum

Upadhyay, Santosh Kumar and Misra, Ashish and Surolia, Namita and Surolia, Avadhesha and Sundd, Monica (2010) Backbone chemical shift assignments of the acyl-acyl carrier protein intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum. In: Biomolecular NMR Assignments .

PDF 13b.pdf - Published Version Restricted to Registered users only Download (244Kb) | Request a copy

Abstract

We report the backbone chemical shift assignments of the acyl-acyl carrier protein (ACP) intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum. The acyl-ACP intermediates butyryl (C4), -octanoyl (C8), -decanoyl (C10), -dodecanoyl (C12) and -tetradecanoyl (C14)-ACPs display marked changes in backbone HN, Cα and Cβ chemical shifts as a result of acyl chain insertion into the hydrophobic core. Chemical shift changes cast light on the mechanism of expansion of the acyl carrier protein core.

Item Type:	Journal Article
Additional Information:	Copy right of this article belongs to Springer Netherlands.
Keywords:	Backbone assignments-Acyl-ACPs-Plasmodium falciparum - Fatty acid biosynthesis
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	30 Apr 2010 09:25
Last Modified:	19 Sep 2010 06:01
URI:	http://eprints.iisc.ernet.in/id/eprint/27423

Actions (login required)

View Item