Gupta, Garima and Surolia, Avadhesha (2010) Glycosphingolipids in microdomain formation and their spatial organization. In: FEBS Letters, 584 (9). 1634 -1641.
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Plasma membranes regulate the influx and efflux of molecules across themselves and are also responsible for primary signal transduction between cells or within the same cell. Presence of lateral heterogeneity and the ability of reorganization are essential requirements for effective functioning of biomembranes. Lipid rafts are small, heterogeneous, dynamic domains enriched in glycosphingolipids, sphingomyelin and cholesterol, and profoundly influence membrane organization. Glycosphingolipids are inclined towards formation of liquid-ordered phases in membranes, both with and without cholesterol; they are therefore prime players in domain formation. Here, we discuss the role of glycosphingolipids in microdomain formation and their spatial organization within these rafts.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Glycosphingolipid; Sphingomyelin; Ganglioside; Sulfatide; Liquid-disordered phase; Microdomain.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||19 May 2010 05:16|
|Last Modified:||19 Sep 2010 06:01|
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