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Metabolism of Plasmodium bergheistar, open: III. Carbon dioxide fixation and role of pyruvate and dicarboxylic acids

Nagarajan, K (1968) Metabolism of Plasmodium bergheistar, open: III. Carbon dioxide fixation and role of pyruvate and dicarboxylic acids. In: Experimental Parasitology, 22 (1). pp. 33-42.

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Official URL: http://dx.doi.org/10.1016/0014-4894(68)90076-3

Abstract

Formation of C4 dicarboxylic acids in Plasmodium berghei by carbon dioxide fixation reaction has been demonstrated by the use of labeled NaH14CO3. The reactions require glucose, which may be required not only as an energy source but also to contribute to the formation of pyruvate in the process of carbon dioxide fixation. Intracellular concentration of pyruvate may play an important role in the metabolism of P. berghei; an increased intracellular level of pyruvate seems to be a prerequisite before some of these reactions could be detected. The distribution of the label indicates extensive randomization of amino acids and suggests an extensive cycling of the amino acid and organic acid pools of the parasites. This investigation formed part of the thesis submitted in 1965 for the doctoral degree at the Indian Institute of Science, Bangalore 12, India, and was supported in part by the Council of Scientific and Industrial Research, India.

Item Type: Journal Article
Additional Information: Copy right of this article belongs to Elsevier Science.
Department/Centre: Others
Date Deposited: 14 May 2010 04:27
Last Modified: 14 May 2010 04:27
URI: http://eprints.iisc.ernet.in/id/eprint/27743

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