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Induction of Infertility in Adult Male Bonnet Monkeys by Immunization with Phage-Expressed Peptides of the Extracellular Domain of FSH Receptor

Rao, AJ and Ramachandra, SG and Ramesh, V and Couture, L and Abdennebi, L and Salesse, R and Remy, JJ (2004) Induction of Infertility in Adult Male Bonnet Monkeys by Immunization with Phage-Expressed Peptides of the Extracellular Domain of FSH Receptor. In: Reproductive Biomedicine Online, 8 (4). pp. 385-391.

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Official URL: http://dx.doi.org/10.1016/S1472-6483(10)60921-2

Abstract

Active immunization of proven fertile adult male bonnet monkeys (Macaca radiata) with phage-expressed follicle stimulating hormone receptor (FSHR) -specific peptides from the extracellular domain resulted in a progressive drop in sperm count with all animals becoming azoospermic by day 100. However, serum testosterone concentrations were unaltered during the entire course of study and animals exhibited normal mating behaviour. Breeding studies with proven fertile female monkeys revealed that all the immunized males were infertile. Following interuption of immunization on day 225, sperm counts returned to normal with restoration of fertility. These results indicate that infertility can be induced in adult male monkeys by interfering with the action of FSH using specific peptides of the extracellular domain of FSHR as antigens, without the risk of producing cross-reacting antibodies to the other glycoprotein hormones.

Item Type: Journal Article
Additional Information: The copyright for this article belongs to Reproductive Healthcare Limited.
Keywords: antifertility agent;follicle stimulating hormone;libido; non-human primate;spermatogenesis;testosterone
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 18 Feb 2005
Last Modified: 22 Feb 2012 06:47
URI: http://eprints.iisc.ernet.in/id/eprint/2795

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