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Biosynthesis of β-N-oxalyl-l-α,β-diaminopropionic acid, the lathyrus sativus neurotoxin

Malathi, K and Padmanaban, G and Sarma, KS (1970) Biosynthesis of β-N-oxalyl-l-α,β-diaminopropionic acid, the lathyrus sativus neurotoxin. In: Phytochemistry, 9 (7). pp. 1603-1610.

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Official URL: http://dx.doi.org/10.1016/S0031-9422(00)85283-8

Abstract

The biosynthesis of β-N-oxalyl-l-α,β-diaminopropionic acid (ODAP) the Lathyrus sativus neurotoxin has been found to follow the scheme depicted below: {A figure is presented}. The first reaction is catalysed by oxalyl-CoA synthetase which has properties similar to that of the enzyme in peas. The second reaction is catalysed by another enzyme which is specific to L. sativus and is designated as oxalyl-CoA-α,β-diaminopropionic acid oxalyl transferase. The enzymes have been purified by about 60-fold and their properties studied. A partial resolution of the two enzyme activities has been achieved using CM-sephadex columns.

Item Type: Journal Article
Additional Information: Copyright of this articlej belongs to Elsevier B.V.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 28 May 2010 10:16
Last Modified: 19 Sep 2010 06:07
URI: http://eprints.iisc.ernet.in/id/eprint/28145

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