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Regulation of hepatic cholesterolgenesis by ubiquinone

Krishnaiah, KV and Ramasarma, T (1970) Regulation of hepatic cholesterolgenesis by ubiquinone. In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 202 (2). pp. 332-342.

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Official URL: http://dx.doi.org/10.1016/0005-2760(70)90195-5

Abstract

The concentration of liver ubiquinone increased progressively with the time of feeding ubiquinone, and this increase was reflected in all the cell fractions. 2. 2. Inhibition of sterol synthesis by ubiquinone was exerted only in the liver, not in the kidney or intestine. 3. 3. Extending the period of feeding ubiquinone or increasing the concentration of ubiquinone fed had no effect on the extent of inhibition. 4. 4. Inhibition was found to be specific to ubiquinone-9, the natural major homologue in the rat liver; other homologues were ineffective. 5. 5. The site of inhibition by ubiquinone was indicated to be between acetyl-CoA and mevalonate, since there was no change in fatty acid and ketone body synthesis in ubiquinone-fed animals as compared to normal animals.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 01 Jun 2010 11:31
Last Modified: 19 Sep 2010 06:08
URI: http://eprints.iisc.ernet.in/id/eprint/28228

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