Hoonur, Rekha S and Patil, Basavaraj R and Badiger, Dayananda S and Vadavi, Ramesh S and Gudasi, Kalagouda B and Dandawate, Prasad R and Ghaisas, Mahesh M and Padhye, Subhash B and Nethaji, Munirathinam (2010) Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents. In: European Journal of Medicinal Chemistry, 45 (6). pp. 2277-2282.
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Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxyhdeneamino)-3-(2-phenyl)-1,2-dihydroquinazoli n-4(3H)-one (L) were synthesized and characterized The structure of ligand is confirmed by single crystal X-ray diffraction studies The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand (C) 2010 Elsevier Masson SAS All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Dihydroquinazoline;Hydrazone;Metal complex;Analgesic activity;Anti-inflammatory activity|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||23 Jun 2010 10:31|
|Last Modified:||19 Sep 2010 06:08|
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