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Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents

Hoonur, Rekha S and Patil, Basavaraj R and Badiger, Dayananda S and Vadavi, Ramesh S and Gudasi, Kalagouda B and Dandawate, Prasad R and Ghaisas, Mahesh M and Padhye, Subhash B and Nethaji, Munirathinam (2010) Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents. In: European Journal of Medicinal Chemistry, 45 (6). pp. 2277-2282.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2010.01.072

Abstract

Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxyhdeneamino)-3-(2-phenyl)-1,2-dihydroquinazoli n-4(3H)-one (L) were synthesized and characterized The structure of ligand is confirmed by single crystal X-ray diffraction studies The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand (C) 2010 Elsevier Masson SAS All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Dihydroquinazoline;Hydrazone;Metal complex;Analgesic activity;Anti-inflammatory activity
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 23 Jun 2010 10:31
Last Modified: 19 Sep 2010 06:08
URI: http://eprints.iisc.ernet.in/id/eprint/28365

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