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Fatty acid specificity for the esterification of vitamin A and cholesterol by intestinal and pancreatic enzymes in rats

Murthy, SK and Mahadevan, S and Sastry, PS and Ganguly, J (1961) Fatty acid specificity for the esterification of vitamin A and cholesterol by intestinal and pancreatic enzymes in rats. In: Nature, 189 (4763). p. 482.

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Official URL: http://www.nature.com/nature/journal/v189/n4763/ab...

Abstract

VITAMIN A and cholesterol esters have been shown to undergo extensive hydrolysis in the lumen of the small intestine during the process of absorption; they are re-esterified to appear in the lymph mostly as esters1,2. However, the vitamin A esters of the lymph, blood and liver of the rat are formed by long-chain fatty acids3 and in the normal rat liver, probably as palmitates4. On the other hand, cholesterol esters are usually made up of poly-unsaturated fatty acids in the lymph and blood of rats5. For the absorption of the two lipid materials, the enzymes of the pancreas have been largely implicated, while not much attention has been paid to the possible role of the mucosal enzymes. From the behaviour of the mucosal enzymes, as presented here, it appears that probably these enzymes play a more important part in the re-esterification of the two lipid materials during their absorption.

Item Type: Editorials/Short Communications
Additional Information: Copyright of this article belongs to Nature Publishing Group.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 15 Jun 2010 11:25
Last Modified: 15 Jun 2010 11:25
URI: http://eprints.iisc.ernet.in/id/eprint/28421

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