Bhattacharya, S and Varadarajan, R (2010) Emerging trends at the interface of chemistry and biology: Applications to the design of human therapeutics. In: Journal of Chemical Sciences, 122 (2). pp. 97-107.
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This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||Multi-target therapeutics; network biology; gene delivery; protein therapeutics; protein design|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit
Division of Chemical Sciences > Organic Chemistry
|Date Deposited:||14 Jul 2010 05:11|
|Last Modified:||19 Sep 2010 06:10|
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