Shinde, UP and Guru, Row TN and Mawal, YR (1989) Export of proteins across membranes: The helix reversion hypothesis. In: Bioscience Reports, 9 (6). pp. 737-745.
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A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||protein export;conformational changes;leader peptides;hairpin helix.|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||16 Jul 2010 06:24|
|Last Modified:||19 Sep 2010 06:11|
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