Kumar, Arun (1999) Genomic imprinting: mom and dad (epi) genetics. In: Journal of Biosciences, 24 (1). pp. 4-6.
Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. A gene could be maternally imprinted (only paternal copy expressed) or paternally imprinted (only maternal copy expressed). The exact mechanism of genomic imprinting is not clear. However, allele-specific methylation of CpG residues at the 5' end of imprinted genes is thought to be responsible for the maintenance of imprinting in somatic cells.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Indian Academy of Sciences.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)|
|Date Deposited:||18 Mar 2005|
|Last Modified:||19 Sep 2010 04:18|
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