Genomic imprinting: mom and dad (epi) genetics

Kumar, Arun (1999) Genomic imprinting: mom and dad (epi) genetics. In: Journal of Biosciences, 24 (1). pp. 4-6.

Preview

PDF genomic.pdf Download (456Kb)

Abstract

Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. A gene could be maternally imprinted (only paternal copy expressed) or paternally imprinted (only maternal copy expressed). The exact mechanism of genomic imprinting is not clear. However, allele-specific methylation of CpG residues at the 5' end of imprinted genes is thought to be responsible for the maintenance of imprinting in somatic cells.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited:	18 Mar 2005
Last Modified:	19 Sep 2010 04:18
URI:	http://eprints.iisc.ernet.in/id/eprint/2944

Actions (login required)

View Item