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Genomic imprinting: mom and dad (epi) genetics

Kumar, Arun (1999) Genomic imprinting: mom and dad (epi) genetics. In: Journal of Biosciences, 24 (1). pp. 4-6.

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Abstract

Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. A gene could be maternally imprinted (only paternal copy expressed) or paternally imprinted (only maternal copy expressed). The exact mechanism of genomic imprinting is not clear. However, allele-specific methylation of CpG residues at the 5' end of imprinted genes is thought to be responsible for the maintenance of imprinting in somatic cells.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited: 18 Mar 2005
Last Modified: 19 Sep 2010 04:18
URI: http://eprints.iisc.ernet.in/id/eprint/2944

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