Sharada, Gullapalli and Vidya, Shivaswamy and Ramasarma, T and Ramakrishna, Kurup CK (1989) Redistribution of subcellular calcium in rat liver on administration of vanadate. In: Molecular and Cellular Biochemistry, 90 (2). pp. 155-164.
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Mitochondria isolated from the livers of rats administered with sodium meta-, ortho-, or polyvanadate, but not vanadyl sulphate, exhibited enhanced Ca2+ — stimulated respiration and uptake of calcium. These effects were shown also by mitochondria isolated from livers perfused with polyvanadate. The concentration of acid-soluble calcium decreased significantly in the mitochondrial fraction on vanadate treatment, while that in the cytosol showed a corresponding increase. Phenoxybenzamine, an antagonist to a-adrenergic receptors, effectively inhibited vanadate-induced Ca2+ mobilization, but surgical sympathectomy was without effect. This is the first demonstration of vanadate mimicking agr-adrenergic agonists in vivo.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||polyvanadate;mitochondria;calcium;pyruvate dehydrogenase; receptors.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||03 Aug 2010 08:48|
|Last Modified:||19 Sep 2010 06:13|
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