Brahmachari, SK and Mishra, RK and Bagga, R and Ramesh, N (1989) DNA duplex with the potential to change handedness after every half a turn. In: Nucleic Acids Research, 17 (18). pp. 7273-7281.
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Polymorphic forms of the DNA duplex with long stretches of structural monotony are known. Several alternating purine-pyrimidine sequences have been shown to adopt left-handed Z-conformation. We report a DNA sequence d(CGCGCGATCGAT)n exhibiting alternating right-handed B and left-handed Z helical conformation after every half a turn. Further, this unusual conformation with change in handedness after every six base pairs was induced at physiological superhelical density.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Oxford University Press.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||05 Aug 2010 11:03|
|Last Modified:||19 Sep 2010 06:13|
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