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Metabolism of a monoterpene ketone, R-(+)-pulegone—a hepatotoxin in rat

Moorthy, B and Madyastha, P and Madyastha, KM (1989) Metabolism of a monoterpene ketone, R-(+)-pulegone—a hepatotoxin in rat. In: Xenobiotica, 19 (2). pp. 217-224.

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Abstract

R-(+)-Pulegone was administered orally to rats and the urinary metabolites were investigated. Six metabolites were isolated and purified using column and thin layer chromatographic techniques. Metabolites were identified by i.r., n.m.r. and mass spectral analyses.The neutral metabolites isolated from urine of rats treated with pulegone (I) were: pulegol (II), 2-hydroxy-2(1'-hydroxy-1'-methylethyl)-5-methylcyclohexanone (III), 3,6-dimethyl-7a-hydroxy-5,6,7,7a-tetrahydro-2(4H)-benzofuranone (V) and menthofuran (VII). Metabolites II and III were also excreted in conjugated form.Acidic metabolites isolated from urine of rats treated with pulegone (I) were: 5-methyl-2(1'-methyl-1'-carboxyethylidene)cyclohexanone (IV) and 5-methyl-5-hydroxy-2(1'hydroxy-'-carboxyethyl)cyclohexanone (VI).

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Informa plc.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 27 Aug 2010 10:09
Last Modified: 27 Aug 2010 10:09
URI: http://eprints.iisc.ernet.in/id/eprint/31571

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