# Stereochemically Constrained Linear Peptides. Conformations of Peptides Containing \alpha-Aminoisobutyric Acid

Nagaraj, R and Shamala, N and Balaram, P (1979) Stereochemically Constrained Linear Peptides. Conformations of Peptides Containing \alpha-Aminoisobutyric Acid. In: Journal of the American Chemical Society, 101 (1). pp. 16-20.

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1H NMR studies of the protected \alpha-aminoisobutyric acid containing peptides Z-Aib-Pro-Aib-Ala-OMe and Z-Aib-Pro-Aib-OMe suggest that these molecules adopt well-defined conformations in solution. Evidence for type III \beta-bend structures is presented and an incipient $3_{10}$ helical conformation is proposed for the tetrapeptide. The interpretation of the NMR data is further substantiated by the crystal structure of the tetrapeptide. which shows two consecutive type III \beta bends in the solid state.