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Homologous Cholinergic Fluorescent Probes. Synthesis and Fluorescence Properties

Narayanan, R and Balaram, P (1978) Homologous Cholinergic Fluorescent Probes. Synthesis and Fluorescence Properties. In: FEBS Letters, 93 (1). pp. 38-42.

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Abstract

The advantages of using specifically designed fluorescent molecules to probe ligand binding sites on proteins, have been recognised [1]. Cholinesterases [2-4], acetylcholine receptor rich fragments from Torpedo marmorata[5,6] and an acetylcholine binding lipoprotein [7] have been studied using fluorescent trialkylammonium ligands. In these investigations, the probes incorporated an ethane [7] or propane bridge [3,5] between the fluorescent dansyl group and the trimethylammonium moiety. During the course of studies of cholinergic ligand binding to mammalian cell plasma membranes, we became aware of the need for developing cholinergie fluorescent probes with increased lipid solubility and higher binding affinities.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier Science Ltd.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 18 May 2005
Last Modified: 19 Sep 2010 04:18
URI: http://eprints.iisc.ernet.in/id/eprint/3216

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