Dhanasekaran, N and Moudgal, NR (1988) Gonadotropin regulation of rat ovarian lysosomes: Existence of a hormone specific dual control mechanism. In: Bioscience Reports, 8 (3). pp. 279-285.
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Gonadotropic hormones PMSG (15 IU/rat), FSH (3 mgrg/rat), LH (9 mgrg/rat) and hCG (3 mgrg/rat) were shown to decrease the free cytosolic lysosomal enzymes during the acute phase of hormone action in rat ovaries. When isolated cells from such rats were analyzed for the cathepsin-D activity, the granulosa cells of the ovary showed a reduction in the free as well as in the total lysosomal enzyme activities in response to FSH/PMSG; the stromal and thecal compartment of the ovary showed a reduction only in the free activity in response to hCG/PMSG. The results suggest the presence of two distinct, target cell specific, mechanisms by which the lysosmal activity of the ovary is regulated by gonadotropins.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||18 Sep 2010 11:20|
|Last Modified:||19 Sep 2010 06:16|
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