Ch, Rajasekhar and Madras, Giridhar (2010) An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide. In: Thermochimica Acta, 507-08 . pp. 99-105.
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The equilibrium solubility of a pharmaceutical compound. 1,5-dimethy1-2-phenyl-4-propan-2-ylpyrazol-3-one (propyphenazone, isopropylantipyrine) in supercritical carbon dioxide (SCCO2) was experimentally determined by a saturation method at 308, 318 and 328 K. over the pressure range of 9.0-19.0 MPa. The solubility data satisfied the self-consistency test, proposed by Mendez-Santiago and Teja. A new association model was derived to correlate the solubilities of pharmaceutical compounds in SCCO2. Solubility data from 54 different pharmaceutical compounds including steroids, antibiotics, anti-inflammatory, antioxidants, statins and specific functional drugs were collected from literature. The model successfully correlated the experimental results for the solubilities of all these compounds in SCCO2 within 12% AARD. (C) 2010 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Solubilities; Association model;Isopropylantipyrine;Drugs; Supercritical fluids.|
|Department/Centre:||Division of Mechanical Sciences > Chemical Engineering|
|Date Deposited:||20 Sep 2010 07:28|
|Last Modified:||20 Sep 2010 07:28|
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