Mishra, Rakesh K and Latha, PK and Brahmachari, Samir K (1988) Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution. In: Nucleic Acids Research, 16 (10). pp. 4651-4665.
Interruptions_of_(CG)._sequences_by_GG,_TG.pdf - Published Version
Restricted to Registered users only
Download (1076Kb) | Request a copy
Oligonucleotides containing alternating purines-pyrimidines with AT base pairs have been shown to exist in the Z-form preferably in solid state. We report that oligodeoxyribonucleotides with GG, TG and CA interruptions in their alternating CG sequences can undergo B to Z transition in solution in the absence of any chemical modification or topological constraint. The sequences, d(CGCGCGGCGCGC) and d(CGTGCGCACG) have been synthesised and shown to adopt Z- conformation in presence of millimolar concentrations of Ni2+ under low water activity conditions. Significance of GG, TG and CA interruptions in the B to Z transition is discussed.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Oxford University Press.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||19 Nov 2010 06:07|
|Last Modified:||19 Nov 2010 06:07|
Actions (login required)