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Pharmacokinetics and chemotherapeutic efficacy of adriamycin encapsulated in immunoliposomes against avian myeloblastosis virus infection

Dhananjaya, KVR and Antony, A (1988) Pharmacokinetics and chemotherapeutic efficacy of adriamycin encapsulated in immunoliposomes against avian myeloblastosis virus infection. In: Journal of Virological Methods, 19 (2). 121-129 .

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Official URL: http://dx.doi.org/10.1016/0166-0934(88)90155-3

Abstract

Immunoliposomes were prepared using rabbit anti-AMV gp80 IgG for the targeted chemotherapy of avian myeloblastosis virus infection. Adriamycin was encapsulated into immunoliposomes and used for in vivo studies. Comparative pharmacokinetics of free drug, drug encapsulated in free liposomes and of drug encapsulated in immunoliposomes in the virus-infected cells revealed that (i) the drug encapsulated in liposomes was cleared from the plasma slowly, and (ii) the drug encapsulated in immunoliposomes accumulated in the target tissue, the bone marrow, 5- and 8.5-fold more than the drug encapsulated in free liposomes and free drug, respectively. The drug encapsulated in immunoliposomes inactivated the virus and exhibited more chemotherapeutic efficacy as compared to controls when injected up to 24 h post-infection. However, when injected 48 h post-infection the drug encapsulated in immunoliposomes did not offer any protection against the virus infection. There is no detectable antibody response against immunoliposomes in the infected animals.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier science.
Keywords: Immunoliposomes;Adriamycin;Pharmacokinetics;Drug targeting; Avian myeloblastosis;Virus infection.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 25 Sep 2010 06:30
Last Modified: 25 Sep 2010 06:30
URI: http://eprints.iisc.ernet.in/id/eprint/32446

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