Chandrasekhar, Sosale and Sridhar, Malayalam (2000) A bifunctional approach towards the mild oxidation of organic halides: 2-dimethylamino-N,N-dimethylaniline N-oxide. In: Tetrahedron Letters, 41 (28). 5423-5425 .
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The titled reagent incorporates an oxygen-centred nucleophile and a basic moietyï¿½in a suitably mutual orientationï¿½in the same molecule. It oxidises various primary benzylic bromides to the corresponding aromatic aldehydes under relatively mild conditions (MeCN/rtï¿½50°C/6ï¿½24 h) in high yields (83ï¿½97%), and is thus a useful alternative to the Kornblum procedure.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||30 Sep 2010 10:05|
|Last Modified:||30 Sep 2010 10:05|
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