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Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide

Ramesh, Kashi S and Rao, Appaji N (1978) Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide. In: Biochemical Journal, 174 (3). pp. 1055-1058.

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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC118601...

Abstract

The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.

Item Type: Editorials/Short Communications
Additional Information: Copyright of this article belongs to Portland Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Oct 2010 06:48
Last Modified: 11 Oct 2010 06:48
URI: http://eprints.iisc.ernet.in/id/eprint/32944

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