Ramesh, Kashi S and Rao, Appaji N (1978) Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide. In: Biochemical Journal, 174 (3). pp. 1055-1058.
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The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.
|Item Type:||Editorials/Short Communications|
|Additional Information:||Copyright of this article belongs to Portland Press.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||11 Oct 2010 06:48|
|Last Modified:||11 Oct 2010 06:48|
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