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Effect of undernutrition on the metabolism of phospholipids and gangliosides in developing rat brain

Reddy , PV and Sastry , PS (1978) Effect of undernutrition on the metabolism of phospholipids and gangliosides in developing rat brain. In: British Journal of Nutrition, 40 (3). pp. 403-411.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/718822

Abstract

1. Phospholipid content of brains of 3- or 8-week-old undernourished rats was 7--9% less than that for the corresponding control animals and this deficit could not be made up by rehabilitation. Phosphatidyl ethanolamine and plasmalogen were the components most affected in brains of undernourished rats. 2. Incorporation of 32P into phospholipids by brain homogenates was 28% higher in 3-week-old undernourished rats. It is suggested that enhanced phospholipid metabolism in undernourished animals may be related to behavioural alterations noted previously (Sobotka, Cook & Brodie, 1974). 3. Ganglioside concentrations in 3- and 8-week-old undernourished animals were 14% and 11.5% less respectively than those of the control animals and this difference could be made up by rehabilitation. [14C]Glucosamine incorporation in vivo into brain gangliosides was not affected by undernutrition.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Cambridge University Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 06 Oct 2010 09:55
Last Modified: 06 Oct 2010 09:55
URI: http://eprints.iisc.ernet.in/id/eprint/32979

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