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Studies on the metabolism of l-menthol in rats

Madyastha, KM and Srivatsan, V (1988) Studies on the metabolism of l-menthol in rats. In: Drug Metabolism and Disposition, 16 (5). pp. 765-772.

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Official URL: http://dmd.aspetjournals.org/content/16/5/765.abst...

Abstract

Metabolism of l-menthol in rats was investigated both in vivo and in vitro. Metabolites isolated and characterized from the urine of rats after oral administration (800 mg/kg of body weight/day) of l-menthol were the following: p-menthane-3,8-diol (II), p-menthane-3,9-diol (III), 3,8-oxy-p-menthane-7-carboxylic acid (IV), and 3,8-dihyroxy-p-menthane-7-carboxylic acid (V). In vivo, the major urinary metabolites were compounds II and V. Repeated oral administration (800 mg/kg of body weight/day) of l-menthol to rats for 3 days resulted in the increase of both liver microsomal cytochrome P-450 content and NADPH-cytochrome c reductase activity by nearly 80%. Further treatment (for 7 days total) reduced their levels considerably, although the levels were still higher than the control values. Both cytochrome b5 and NADH-cytochrome c reductase levels were not changed during the 7 days of treatment. Rat liver microsomes readily converted l-menthol to p-menthane-3,8-diol (II) in the presence of NADPH and O2. This activity was significantly higher in microsomes obtained from phenobarbital (PB)-induced rats than from control microsomal preparations, whereas 3-methylcholanthrene (3-MC)-induced microsomes failed to convert l-menthol to compound II in the presence of NADPH and O2. l-Menthol elicited a type I spectrum with control (Ks = 60.6 microM) and PB-induced (Ks = 32.3 microM) microsomes whereas with 3MC-induced microsomes it produced a reverse type I spectrum.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Society for Pharmacology and Experimental Therapeutics.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 05 Oct 2010 09:41
Last Modified: 05 Oct 2010 09:41
URI: http://eprints.iisc.ernet.in/id/eprint/32980

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